What does Poole think has happened to Dr Jekyll?

Poole appears quite distraught, and Utterson offers him a glass of wine to calm his nerves. Poole accepts, although he leaves the wine untouched. Poole reveals that he has come to Utterson in desperation. He is severely concerned about Dr. Jekyll's well being, as the man has been locked in his cabinet for weeks and allows no one to see him. Poole admits that he believes there has been "foul play", but refuses to go into specifics.