Hamlet

" O, my offence is rank, it smells to heaven. It hath the primal eldest curse upon't, a brother's murder."

Who is the speaker and significance, Hamlet-Act II and III

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Claudius is praying to God. He knows he holds the "Primal" curse of killing one's brother (think Cane and Abel, Old Testament). He knows he can't be forgiven while he holds the throne and is still married to the queen.