By the end of Scene 2 how does macbeth feel about his crime?

Macbeth is having killer's remorse. Macbeth regrets what he has done. Macduff and company are knocking at the door. The sound causes Macbeth to lament on what he has done,

"To know my deed, 'twere best not know myself. "

"Wake Duncan with thy knocking! I would thou couldst! "

He wishes that he had never been born because of what he has done.