How does the setting of Of Mice and Men influence the book's thematic development? In answering, consider the connection between the novel's setting and the characters' vocations.

Though the novel is more famous for its characters than its setting, Of Mice and Men could not have been set elsewhere than in the rural Salinas valley of California. The problems of the novel are intimately tied to the rhythms and frustrations of the itinerant worker's life. Shifting from ranch to ranch, from one menial job to another, the Californian itinerant worker risked a life of meaningless labor - of pure, cynical sustenance. George and Lennie, with their dream of acquiring a farm, represent an attempt to stand against such perpetual loneliness. Even the name of the city near which the novel is set - Soledad, which is Spanish for "solitude" - resonates with this theme of loneliness.