From Chapter 1

Watson and Holmes are longtime friends. They've worked together and have a unique bond of friendship. Holmes use of drugs, however, has created a chasm. Watson is concerned about Holme's health. He has also published an account of their most recent case in honor of his friend.... Holmes not only criticizes Watson's work, but he demeans Watson's brother as well.

“But consider!” I said, earnestly. “Count the cost! Your brain may, as you say, be roused and excited, but it is a pathological and morbid process, which involves increased tissue-change and may at last leave a permanent weakness. You know, too,
what a black reaction comes upon you. Surely the game is hardly worth the candle. Why should you, for a mere passing pleasure, risk the loss of those great powers with which you have been endowed? Remember that I speak not only as one comrade to another, but as a medical man to one for whose constitution he is to some extent answerable.”

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“Yes, indeed,” said I, cordially. “I was never so struck by anything in my life. I even embodied it in a small brochure with the somewhat fantastic title of ‘A Study in Scarlet.’ ”
He shook his head sadly. “I glanced over it,” said he. “Honestly, I cannot congratulate you upon it. Detection is, or ought to be, an exact science, and should be treated in the same cold and unemotional manner. You have attempted to tinge it with romanticism, which produces much the same effect as if you worked a love-story or an elopement into the fifth proposition of Euclid.”

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“He was a man of untidy habits,—very untidy and careless. He was left with good prospects, but he threw away his chances, lived for some time in poverty with occasional short intervals of prosperity, and finally, taking to drink, he died. That is all I can gather.”
I sprang from my chair and limped impatiently about the room with considerable bitterness in my heart.
“This is unworthy of you, Holmes,” I said. “I could not have believed that you would have descended to this. You have made inquires into the history of my unhappy brother, and you now pretend to deduce this knowledge in some fanciful
way. You cannot expect me to believe that you have read all this from his old watch! It is unkind, and, to speak plainly, has a touch of charlatanism in it.”