How might this novel have affected popular opinion of slavery

The book began as a series of stories throughout 1851-52 for the National Era, a Washington abolitionist newspaper. Upon its publication in 1852 by the Boston publishing company Jewett, Uncle Tom's Cabin became so popular that it sold more copies than any book before that with the acception of the Bible. Stowe toured the United States and Europe to speak against slavery and wrote A Key to Uncle Tom's Cabin a year later, in 1853, to provide documentation of the truth upon which her novel is based.