Mark Antony
Triumvir. One third of the triumvirate, the alliance between Antony, Octavius, and Lepidus that rules the Roman Empire. Antony is a great general, beloved by his men. He is middle-aged. He is also a lover of pleasure, far less single-minded than Octavius. He is a complicated and fatally divided man, failing to rise to the task of generalship at key points. Plutarch represents his love for Cleopatra as the cause of his doom, and Shakespeare shares this view, but the play also shows their love as a kind of triumph, beautiful and wonderful on its own terms.
Cleopatra
Queen of Egypt. She is the last of the Greek dynasty that began its rule over Egypt, centuries before, with Ptolemy. (Ptomely was a general under Alexander the Great who inherited the Egyptian part of Alexander's empire after Alexander's death.) Cleopatra is the lover of Antony, and others in the past, including the deceased Julius Caesar. She is middle-aged. Cleopatra is one of Shakespeare's most accomplished creations, an intriguing woman who wraps great men around her finger. She is possessive, commanding, dramatic. She is complicated and fickle. Her own emotions are of supreme importance to her, and she has a violent temper. Her personal charisma far exceeds her talents as a strategist, and her interference partly causes Antony's defeat. Her final suicide is not done according to the precepts of a Roman conception of honor, but rather because she will allow no fundamental compromise to her persona. She will not be paraded through the streets as Caesar's trophy.
Octavius Caesar
Triumvir. Julius Caesar's nephew and adopted son. Destined to become Augustus, the ruler of the Roman Empire. Referred to both as "Caesar" and "Octavius." He is much younger than Antony. As in Julius Caesar, Octavius is depicted in Antony and Cleopatra as possessing nearly inhuman detachment and self-control. He is a cold, calculating, political animal. He uses Antony when he needs him, and turns on both Antony and Lepidus when he can. But he is not malicious. He is single-minded. His ambition is of a single empire, ruled by a single Emperor, and war will be his tool for achieving a universal peace in the Mediterranean world. He is not nearly as good a field commander as Antony, but his absolute devotion to his ambition proves decisive.
M. Aemilius Lepidus
Triumvir. The lame duck of the triumvirate. Lepidus is not a serious contender for power. Octavius disposes of him as soon as it becomes politically expedient.
Sextus Pompeius
His father was Pompey the Great, a popular Roman general who shared power with Caesar in the first triumvirate. Sextus Pompeius, aka Pompey, is a formidable threat to the triumvirate. His power by sea is threatening enough to force the triumvirate to put aside their differences. Although he has an opportunity to slay the triumvirate while they are guests aboard his ship, he refuses out of his sense of honor.
Domitius Enobarbus
Friend to Antony. An officer, one of Antony's closest friends and supporters. Enobarbus is a cynical observer of the events of the play, disapproving of Antony often but always speaking from a complex and sophisticated perspective. His sense of irony runs deep, and he is completely outspoken until his master begins to lose self-control. His penetrating insights make him one of the play's most memorable characters. After he has betrayed Antony, Enobarbus' keen insight is turned on himself, and he dies of grief.
Ventidius
A gifted officer of Antony, blessed also with political savvy. When victorious against Rome's formidable enemy, the Parthian Empire, Ventidius is careful not to capitalize too well on his victories, as too much success for an officer can lead to a superior's fear, envy, and suspicion. Although not at all integral to the central story of the play, Ventidius' scene (3.1) speaks volumes about the volatile politics of the Roman military.
Eros
One of Antony's attendants. With Octavius' victory close, Antony asks Eros to kill him (4.14). Eros kills himself instead.
Scarus
Friend to Antony, brave soldier and faithful companion.
Decretas
Friend to Antony. After Antony's suicide, Decretas brings Antony's bloody sword to Caesar.
Demetrius
Friend to Antony. At the beginning of the play, he and Philo speak disapproving of Antony's affair with Cleopatra.
Philo
Friend to Antony. At the beginning of the play, he and Demetrius speak disapprovingly of Antony's affair with Cleopatra.
Canidius
Lieutenant general to Antony. After Antony's shocking desertion of his own men at Actium, Canidius defects to Caesar's camp
Silius
An officer in Ventidius' army
Maecenas
Friend to Caesar.
Agrippa
Friend to Caesar
Dolabella
Friend to Caesar. He guards the captured Cleopatra, and helps her to preserve her honor.
Proculeius
Friend to Caesar. Antony warns Cleopatra to trust none in Caesar's camp but Proculeius, but in the end Dolabella proves her greatest friend.
Thidias
Friend to Caesar. Messenger. When Caesar's messages to Antony enrage him, Antony has the unfortunate Thidias whipped.
Gallus
Friend to Caesar.
Taurus
Lieutenant general to Caesar.
Menas
One of Pompey's men. When Pompey entertains the triumvirate as guests aboard his barge, Menas asks if he should murder the three men and make Pompey the world's master.
Menecrates
Friend to Pompey.
Varrius
Friend to Pompey.
Alexas
Attendant on Cleopatra.
Mardian
Attendant on Cleopatra. A eunuch. He brings Antony the false news that Cleopatra is dead.
Seleucus
Attendant on Cleopatra. Her spineless treasurer, who betrays her when she's down.
Diomedes
Attendant on Cleopatra. He brings Antony the news that the queen is still living.
A Soothsayer
He predicts many things, although some of his predictions are masked. He tells Charmian that she will outlive her mistress, which she does, but only by a few moments. He warns Antony that whenever Antony contests with Octavius, he will lose.
A Clown
Deliverer of the asp that kills Cleopatra.
Charmian
Attendant on Cleopatra. This devoted lady in waiting follows her mistress even unto death. Her memorable last words are taken directly from Plutarch.
Iras
Attendant on Cleopatra. Another lady-in-waiting. Saucy and high-spirited, she also proves loyal enough to join her mistress in suicide.