Principles of Anatomy and Physiology 14e with Atlas of the Skeleton Set (14th Edition)

Published by Wiley
ISBN 10: 1-11877-456-6
ISBN 13: 978-1-11877-456-4

Chapter 22 - The Lymphatic System and Immunity - Figure 22.22 - Page 829: 1

Answer

In the process of deletion selected T-cells or B cells die by apoptosis

Work Step by Step

Cells (B cells or T cells) that develop anergy remain alive, but are not able to respond to antigens. Of the many pre-T cells that go to the thymus only those survive that do not react to self antigens. Elimination is by apoptosis (deletion). Some of the surviving T-cells become incapable of responding to antigenic stimulation. This is the condition of anergy. Only about 3% of the pre-T cells that go to the thymus for differentiation, emerge as mature immunocompetent T cells
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