Principles of Anatomy and Physiology 14e with Atlas of the Skeleton Set (14th Edition)

Published by Wiley
ISBN 10: 1-11877-456-6
ISBN 13: 978-1-11877-456-4

Chapter 25 - Metabolism and Nutrition - Critical Thinking Questions - Page 978: 1

Answer

Cyanide adversely affects aerobic cellular respiration (Krebs Cycle). When cyanide enters cells it binds to the cytochrome oxidase complex in the inner mitochondrial membranes. The binding of the CN- ion to cytochrome oxidase prevents the transport of electrons to oxygen in the electron transport chain of the Krebs cycle. This makes it impossible for the mitochondria to produce ATP, the energy molecule of cells. In this situation the cells of heart and nervous system quickly use up their stored energy and die. When enough cells die, the organism is unable to function and death ensues.

Work Step by Step

Some of early the symptoms and signs (SS) of cyanide poisoning are headache, anxiety, dizziness, restlessness, nausea vomiting, and shortness of breath (SOB). This is a serious medical emergency and 911 should be called immediately. A subject may want to wash off traces of poison and remove contaminated garments, but this is not a case for self-treatment Medical treatment usually involves oxygen therapy , cyanide antidotes and charcoal.
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