Answer
Stiffening of tissues occur as individuals age. One proposed cause for this development is the increasing irreversible cross-linking of tissue proteins which is promoted and facilitated by glucose in body fluids.
Work Step by Step
There may be other factors that influence this process; for example, telomere shortening, damage and loss of chromosomal DNA cholesterol interaction with protein molecule are all factors that promote aging changes; in addition autoimmune reactions which cause tissue damage increase with advancing age and must be factored in.
