Essential Cell Biology, 4th Edition

Published by Garland Science
ISBN 10: 0815344546
ISBN 13: 978-0-81534-454-4

Chapter 11 - Membrane Structure - Questions - Page 382: Question 11-11

Answer

See explanation

Work Step by Step

Phospholipids and detergents differ primarily in their structure and the type of aggregates they form in water. A phospholipid has a polar, hydrophilic head and two long, nonpolar hydrocarbon tails, giving it a roughly cylindrical shape. This structure allows phospholipids to pack together to form stable bilayers, which are the basis of biological membranes. In contrast, detergents have a polar head but only a single hydrocarbon tail, giving them a cone-like shape. This shape prevents them from forming bilayers and instead promotes the formation of micelles, which can solubilize hydrophobic molecules and disrupt membranes. Essentially, to convert a phospholipid into a detergent, one would remove one of its hydrocarbon tails, creating a cone-shaped molecule that favors micelle formation rather than bilayer assembly.
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