Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 10 - Membrane Transport - Exercises - Page 319: 10

Answer

a) The acetyl choline molecules present in the plasma membrane binds to the receptor which triggers and change in conformation of the receptor leading to the opening of the gate. b) Due to the opening of the gate Na+ ion flow into the cells leading to depolarization. This is due to the the end plate potential developed between the outer and inner environment of the cell, the inside being negative with respect to outside. Sodium hence flows in (due to inner side being -ve with respect to ouside) and causes depolarization. c) Depolarization reduces the membrane potential as outer and inner concentration of both -ve and +ve ions is normalized.

Work Step by Step

a) The acetyl choline molecules present in the plasma membrane binds to the receptor which triggers and change in conformation of the receptor leading to the opening of the gate. b) Due to the opening of the gate Na+ ion flow into the cells leading to depolarization. This is due to the the end plate potential developed between the outer and inner environment of the cell, the inside being negative with respect to outside. Sodium hence flows in (due to inner side being -ve with respect to ouside) and causes depolarization. c) Depolarization reduces the membrane potential as outer and inner concentration of both -ve and +ve ions is normalized.
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