Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 12 - Biosignaling - Problems - Page 497: 5

Answer

$(a)$ No If $V_{m}$. were set by permeability to (primary) $K^{+}$, the Nernst equation would predict a $V_{m}$ of $-$90 mV, not the observed $-$95 mV, So some other conductance must contribute to $V_{m}$. $(b)$ Chloride ion is probably the determinant of $V_{m}$; the predicted $E_{Cl^{-}}$ is $-$94 mV.

Work Step by Step

$(a)$ No If $V_{m}$. were set by permeability to (primary) $K^{+}$, the Nernst equation would predict a $V_{m}$ of $-$90 mV, not the observed $-$95 mV, So some other conductance must contribute to $V_{m}$. $(b)$ Chloride ion is probably the determinant of $V_{m}$; the predicted $E_{Cl^{-}}$ is $-$94 mV.
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