Answer
The main disadvantage of using E. coli for genetic engineering is that it can produce endotoxins as part of its outer layer of the cell, which can produce shock and fever in mammals.
Work Step by Step
As above
Microbiology: An Introduction, 11th Edition
by Tortora, Gerard J.; Funke, Berdell R.; Case, Christine L.
Published by
Benjamin Cummings
ISBN 10:
0321733606
ISBN 13:
978-0-32173-360-3
Chapter 9 - Figure 9.13 - E. coli genetically modified to produce a gamma interferon, a human protein that promotes an immune response - Question - Page 256: 2
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