Tobacco Road tells the story of the Lester family. The Lester family consists of Jeeter and Ada Lester as well as their seventeen children. The Lesters are former cotton farmers (turned tenant farmers) who live in the Southern part of the United States. They live on a crumbling plantation that once belonged to their ancestors, with two of their children. These two children - Ellie May and Dude - cannot afford to live on their own. They are both handicapped - the unmarried daughter has a cleft lip, and the son is mentally disabled.
The Lesters are struggling to get by on their plantation. The Great Depression has turned the American economy upside down, and it's corrupting the Lesters' lives. Unfortunately, they have turned to morally corrupt antics, highlighting the historic racism of Southerners during this time period, among other difficulties.
Erskine Caldwell does a commendable job of emphasizing how socioeconomic hardships negatively impact the psyche and relationships of everyday people. He encourages the reader to tap into their sociological imagination and discover the underlying institutional problems that heighten personal issues. The Lesters become increasingly demoralized as they try to make sense of the uncertainty faced. As a result, the family descends into mayhem, which causes separation and death for some relatives.