The setting is the next day at the same time. Estragon's boots and Lucky's hat are still on the stage. Vladimir enters and starts to sing until Estragon shows up barefoot. Estragon is upset that Vladimir was singing and happy even though he was not there. Both admit that they feel better when alone but convince themselves they are happy when together. They are still waiting for Godot.
Estragon and Vladimir poetically talk about "all the dead voices" they hear. They are haunted by voices in the sounds of nature, especially of the leaves rustling. Vladimir shouts at Estragon to help him not hear the voices anymore. Estragon tries and finally decides that they should ask each other questions. They manage to talk for a short while.
Estragon has forgotten everything that took place the day before. He has forgotten all about Pozzo and Lucky as well as the fact that he wanted to hang himself from the tree. He cannot remember his boots and thinks they must be someone else's. For some reason they fit him now when he tries them on. The tree has sprouted leaves since the night before and Estragon comments that it must be spring. But when Vladimir looks at Estragon's shin, it is still pussy and bleeding from where Lucky kicked him.
Soon they are done talking and try to find another topic for discussion. Vladimir finds Lucky's hat and tries it on. He and Estragon spend a while trading hats until Vladimir throws his own hat on the ground and asks how he looks. They then decide to play at being Pozzo and Lucky, but to no avail. Estragon leaves only to immediately return panting. He says that they are coming. Vladimir thinks that it must be Godot who is coming to save them. He then becomes afraid and tries to hide Estragon behind the tree, which is too small to hide him.
The conversation then degenerates into abusive phrases. Estragon says, "That's the idea, let's abuse each other." They continue to hurl insults at one another until Estragon calls Vladimir a critic. They embrace and continue waiting.
Pozzo and Lucky enter but this time Pozzo is blind and Lucky is mute. Lucky stops when he sees the two men. Pozzo crashes into him and they both fall helplessly in a heap on the ground. Vladimir is overjoyed that reinforcements have arrived to help with the waiting. Estragon again thinks that Godot has arrived.
Vladimir and Estragon discuss the merits of helping Pozzo get off the ground where he has fallen. When Vladimir asks how many other men spend their time in waiting, Estragon replies that it is billions. Pozzo in desperation offers to pay for help by offering a hundred francs. Estragon says that it is not enough. Vladimir does not want to pick up Pozzo because then he and Estragon would be alone again. Finally he goes over and tries to pick him up but is unable to. Estragon decides to leave but decides to stay when Vladimir convinces him to help first and then leave.
While trying to help Pozzo, both Vladimir and Estragon fall and cannot get up. When Pozzo talks again Vladimir kicks him violently to make him shut up. Vladimir and Estragon finally get up, and Pozzo resumes calling for help. They go and help him up. Pozzo asks who they are and what time it is. They cannot answer his questions.
Estragon goes to wake up Lucky. He kicks him and starts hurling abuses until he again hurts his foot. Estragon sits back down and tries to take off his boot. Vladimir tells Pozzo his friend is hurt.
Vladimir then asks Pozzo to make Lucky dance or think for them again. Pozzo tells him that Lucky is mute. When Vladimir asks since when, Pozzo gets into a rage. He tells them to stop harassing him with their time questions since he has no notion of it. He then helps Lucky up and they leave.
Vladimir reflects upon the fact that there is no truth and that by tomorrow he will know nothing of what has just passed. There is no way of confirming his memories since Estragon always forgets everything that happens to him.
The boy arrives again but does not remember meeting Estragon or Vladimir. He tells them it is his first time coming to meet them. The conversation is identical in that Mr. Godot will once again not be able to come but will be sure to arrive tomorrow. Vladimir demands that the boy be sure to remember that he saw him. Vladimir yells, "You're sure you saw me, you won't come and tell me to-morrow that you never saw me!"
The two bums decide to leave but cannot go far since they need to wait for Godot. They look at the tree and contemplate hanging themselves. Estragon takes off his belt but it breaks when they pull on it. His trousers fall down. Vladimir says that they will hang themselves tomorrow unless Godot comes to save them. He tells Estragon to put on his trousers. They decide to leave but again do not move.