Answer
$-2^{6}=-64$
Work Step by Step
$-2^{6}$ is the same as
$-(2\times2\times2\times2\times2\times2)=-(4\times2\times2\times2\times2)=-(8\times2\times2\times2)=-(16\times2\times2)=-(32\times2)=-64$
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