Answer
$40$
Work Step by Step
Substituting $
x=4
$ and $
y=-4
,$ the given expression, $
5(x-y)-9(x+y)
,$ evaluates to
\begin{array}{l}\require{cancel}
5(4-(-4))-9(4+(-4))
\\\\=
5(4+4)-9(4-4)
\\\\=
5(8)-9(0)
\\\\=
40-0
\\\\=
40
.\end{array}