Answer
45
Work Step by Step
If you follow the order of operations, to simplify you must solve the exponents first, then divide and multiply, and finally subtract from left to right.
8$^2$-16$\div$2$^2$$\times$4-3
(64)-16$\div$(4)$\times$4-3
64-(4)$\times$4-3
64-(16)-3
(48)-3
45