Answer
The major difference between an isometric and an orthographic drawing comes down to the point of view in which the 3D figure is drawn.
While in an isometric you have a corner view of the figure, in an orthographic drawing, the model is drawn from 3 separate points of view: the top, the front, and the right.
Work Step by Step
The dotted background in witch an isometric drawing is usually drawn only allows for a certain point of view. While the orthographic drawing is composed by 3 separate illustrations. Which allows for 3 separate perspectives on the 3D figure.