Answer
250
Work Step by Step
18 is larger than 4, so the first step in the long division will be to divide 18 into 45. The quotient of $45 \div 18$ will therefore be placed over the 5 in 4500. Since there must be a digit in the quotient placed above each digit in the dividend, the quotient for $4500 \div 18$ will be a 3 digit answer, with one digit over the 5 and another digit over each 0.
Since 250 is the only 3 digit answer given, 250 is the correct answer choice.