Answer
-45
Work Step by Step
11010011 base 2:
The one in the front of the integer dictates the sign: (1)1010011
Thus the number is negative.
11010011 → 00101100 One's Compliment
00101100 → 00101101 Two's Compliment (Add 1)
00101101 = 00(2^5)0(2^3)(2^2)0(2^0) in base 10
2^5 = 32
2^3 =8
2^2 = 4
2^0 = 1
-(32+8+4+1) = -45