Answer
The classical pathway of activation of complement is joined to cell-mediated immunity because
antigen-antibody complexes activate complement C1.
Work Step by Step
In the classical pathway, antibody binds to antigen. The antigen-antibody complex then binds to C1 and activates it. C1 initiates the eventual activation of C3. The fragments of C3 initiate phagocytosis, inflammation, and cytolysis.
The alternative pathway does not involve antibodies(IgM, IgG).
