Biological Science (6th Edition)

Published by Benjamin Cummings
ISBN 10: 0321976495
ISBN 13: 978-0-32197-649-9

Chapter 3 - Protein Structure and Function - Review - Case Study - Page 92: 14

Answer

The AN-PEP enzymes from mold and its analogous enzymes that do not digest the protein-rich peptide would most likely differ in the primary sequence of the polypeptide that would contribute to forming the active site of the enzyme.

Work Step by Step

The primary sequence of a polypeptide directs the functional three-dimensional tertiary structure of a protein. AN-PEP’s ability to digest proline-rich peptides likely stems from unique structural adaptations in its active site, including flexibility, shape, and residue composition that allow it to overcome the challenges posed by proline’s rigid structure. These features distinguish it from enzymes that fail to process gluten fragments effectively.
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