Answer
While small protein molecules can pass through the nuclear pore complex by passive diffusion, some molecules are left behind. The proteins require the NLS to be identified by the nuclear pore complex for complete nuclear translocation, i.e. to ensure that almost all proteins are transported from the cytoplasm.
Work Step by Step
A nuclear localization signal (NLS) is an amino acid sequence that acts as a tag on proteins and allows their entry into the nucleus of the cell through the nuclear pore complex.
Nuclear transport is heavily regulated to control the entry and exit of substances to and from the nucleus. This dynamic control prevents the movement of substances that do not have the NLS tag as these might harm the nucleus and genetic material.
