Answer
Salmonella typhimurium is an enteric pathogen can cause diseases such as food poisoning that can result in gastroenteritis. The effector protein of the Salmonella typhimurium is SipA. This effector protein assist gastroenteritis through functional motifs (by stimulation of inflammation or entry of bacteria). 41 proteins are cleaved by the caspase-1, which is a cysteine protease & it includes the protein that aids in immunity. S. typhimurium induces a pronounced processing of the proteins, thus preventing glycolysis & causing pyroptosis. Pyroptosis is the caspase-1 dependent cell death subroutine, related to the production of pyrogenic mediators (IL-1 beta etc.) & it becomes a response against the microbe & hence it is advantageous.
Work Step by Step
Salmonella typhimurium is an enteric pathogen can cause diseases such as food poisoning that can result in gastroenteritis. The effector protein of the Salmonella typhimurium is SipA. This effector protein assist gastroenteritis through functional motifs (by stimulation of inflammation or entry of bacteria). 41 proteins are cleaved by the caspase-1, which is a cysteine protease & it includes the protein that aids in immunity. S. typhimurium induces a pronounced processing of the proteins, thus preventing glycolysis & causing pyroptosis. Pyroptosis is the caspase-1 dependent cell death subroutine, related to the production of pyrogenic mediators (IL-1 beta etc.) & it becomes a response against the microbe & hence it is advantageous.
