Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 22 - Mammalian Fuel Metabolism: Integration and Regulation - Exercises - Page 799: 11

Answer

insulin is required for adipocytes to synthesize triacylglycerols from fatty acids because it promotes the uptake and storage of glucose and fatty acids in adipose tissue, thereby helping to regulate energy balance and maintain metabolic homeostasis in the body.

Work Step by Step

Insulin is a hormone that plays a critical function in regulating metabolism and energy homeostasis in the body. Promoting the uptake and storage of glucose and fatty acids in adipose tissue, which is made up of adipocytes, commonly referred to as fat cells, is one of its main tasks. Insulin is essential for adipocytes to generate triacylglycerols from fatty acids because it stimulates the activity of enzymes involved in this process. When insulin attaches to its receptor on the surface of adipocytes, it starts a signaling pathway that ultimately leads to the activation of lipoprotein lipase (LPL), an enzyme that hydrolyzes triglycerides in circulating lipoproteins, such as chylomicrons and very low-density lipoproteins (VLDLs) (VLDLs).
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