Answer
Major differences between nuclear and chemical reactions:
(1) Nuclear reactions involve a change in an atom's nucleus, usually producing a different element. Chemical reactions, on the other hand, involve only a rearrangement of electrons and do not involve changes in the nuclei.
(2) Different isotopes of an element normally behave similarly in chemical reactions. The nuclear chemistry of different isotopes vary greatly from each other.
(3) Rates of chemical reactions are influenced by temperature and catalysts. Rates of nuclear reactions are unaffected by such factors.
(4) Nuclear reactions are independent of the chemical form of the element.
(5) In a nuclear reaction, mass is not strictly conserved. Some of the mass is converted into energy, $E = mc^{2}$
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