The Irony of the Stillborn
Alicia becomes pregnant after she's raped during the insurrection of the previous book in the series. Her child is the product of the debasement of humanity. When the baby is stillborn, it fulfills a prophecy. In giving birth, Alicia has delivered death for there was nothing living inside of her.
The Irony of Amy's Sacrifice
Since being prophesied to defeat Zero, Amy has become the slave of her species. She was bitten, thus being robbed of her very humanity and presence of mind. Then she is kept "safe" for the next decade or so, living in a ship's hold in miserable conditions. She's malnourished and isolated and has basically gone mad. Oddly enough when she's restored to human form, she still insists on fulfilling her quest of killing Zero, despite the awful slavery to which she has been subjected by the people she's trying to save.
The Irony of Escapism
Escapism is characterized by addiction; it's a coping method which buries problems instead of addressing them. Peter is guilty of this when he retires. Trying to forget about all the madness of the previous two novels' events, he lives on a small property in Kervile. Although he's living a remote life, keeping to himself and his simple work on the farm, he still cannot escape the memories of earlier. He finds himself having repeated dreams in which he lives a much different, happier life with Amy. Even during his escape -- moving to the farm -- Peter has to escape even further into a dream world because escapism is never content nor a permanent solution.
The Irony of Michael's Trip to England
After the final battle, Michael has the opportunity to catch the freighter and save himself. He has devoted the past twelve or so years of his life to making this voyage possible in order to save all remaining humans, but he doesn't believe he'll get to go. When he survives the battle, he still chooses to abnegate his certain survival. He sails to England instead, hoping to find any other survivors there and offer his help. He's the one person who deserved to be onboard the freighter, but he declines of his own will.
The Irony of Zero's Murder
In college Zero murders a woman out of rage. He had been stood up at the airport by his true love after inviting her to move to Europe with him. Distraught and furious by her rejection he gets into a fight with this other woman and beats her to death. As he's trying to cover his tracks for the murder, he learns that his lover had died in a car accident on her way to the airport; that's why she never arrived. In a cruel twist of fate Zero finds himself guilty on one hand of murder and on the other of hatred of an innocent woman.
