Answer
Diacyglycerol with the help of calcium ions is responsible for activation of protein kinase C in phosphoinositide pathway. When diacyglycerol kinase gets activated it will convert diacyglycerol to phosphatidic acid. Hence there will no diacyglycerol to activate protein kinase C. This is why activation of diacyglycerol kinase would limit signaling by the phosphoinositide pathway. Diacylglycerol is a substrate for the enzyme diacyglycerol kinase. The product of this reaction is Phosphatidic acid.
Work Step by Step
Diacyglycerol with the help of calcium ions is responsible for activation of protein kinase C in phosphoinositide pathway. When diacyglycerol kinase gets activated it will convert diacyglycerol to phosphatidic acid. Hence there will no diacyglycerol to activate protein kinase C. This is why activation of diacyglycerol kinase would limit signaling by the phosphoinositide pathway. Diacylglycerol is a substrate for the enzyme diacyglycerol kinase. The product of this reaction is Phosphatidic acid.
