Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 18 - Electron Transport and Oxidative Phosphorylation - Exercises - Page 627: 25

Answer

The switch to aerobic metabolism allows ATP to be produced by oxidative phosphorylation. The phosphorylation of ADP increases the [ATP]/[ADP] ratio, which then increases the [NADH]/[NAD] ratio because a high ATP mass action ratio slows electron transport. The increases in [ATP] and [NADH] inhibit their target enzymes in glycolysis and the citric acid cycle and thereby slow these processes.

Work Step by Step

The switch to aerobic metabolism allows ATP to be produced by oxidative phosphorylation. The phosphorylation of ADP increases the [ATP]/[ADP] ratio, which then increases the [NADH]/[NAD] ratio because a high ATP mass action ratio slows electron transport. The increases in [ATP] and [NADH] inhibit their target enzymes in glycolysis and the citric acid cycle and thereby slow these processes.
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