Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 3 - Nucleotides, Nucleic Acids, and Genetic Information - Exercises - Page 78: 24

Answer

The addition of a methyl group on RNA molecule at adenosine results the formation of N-methyl-6-adenosine is also called as m6A. It is the most abundant modification in mammalian mRNAs. The structure is as given below; The modified nucleosides would be able to participate in standard watson crick base pairing but show some modification in functioning and that causes different biological functions of m6A.

Work Step by Step

The addition of a methyl group on RNA molecule at adenosine results the formation of N-methyl-6-adenosine is also called as m6A. It is the most abundant modification in mammalian mRNAs. The structure is as given below; The modified nucleosides would be able to participate in standard watson crick base pairing but show some modification in functioning and that causes different biological functions of m6A.
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