Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 2 - Water - Problems - Page 72: 15

Answer

More aspirin is absorbed from the stomach.

Work Step by Step

The pKa of aspirin is 3.5 and at a pH of 1.5 in the stomach, it is not dissociated. It remains neutral and is rapidly absorbed. In the intestines, where the pH is 6, aspirin dissociates to form ions which are absorbed at much lower rate.
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