K's Humanity
K, a replicant designed and manufactured on an assembly line, acts more compassionate and human than the actual humans in the film.
Blade Runner 2049 Itself
It is quite ironic that Blade Runner 2049 continues and updates the story of a film released over 30 years before it - a film, in fact, about obsolescence. Many would consider updating such an old film both useless and obsolete. It turned out to be quite the opposite: Blade Runner 2049 turned out to be exceptionally fresh and well-reviewed.
Deckard
It's never expressly mentioned if Deckard is a human or a replicant, yet the way he acts suggests he is totally human - even if the film wants us to think that he is a replicant.
Rachel
Rachel is reincarnated in Blade Runner 2049. She shares virtually everything with the original Rachel: her appearance, mannerisms, voice (etc.). Yet, in an ironic turn of events, she doesn't share the original Rachel's soul, something only humans are thought to possess (when Rachel, in fact, is a replicant).
Dr. Ana Stelline
Dr. Ana Stelline is a replicant, yet audiences aren't sure if her father, Deckard, is a replicant and aren't sure if she's a full-blooded replicant. Like Deckard, she is an enigma - audiences don't know if she's a replicant, human, or a little bit of both.
