Answer
$\frac{3}{8}$
Work Step by Step
$1 - (\frac{1}{4} + \frac{3}{8})$ (Convert all numbers to have a denominator of 8)
$= \frac{8}{8} - (\frac{2}{8} + \frac{3}{8})$ (Add the fractions in the brackets)
$= \frac{8}{8} - \frac{5}{8}$ (Complete the subtraction)
$= \frac{3}{8}$