Answer
SHP-2 is a Src homology domain containing protein tyrosine phosphatase (PTP) takes part in regulation of many cellular biological processes. Phosphatases dephosphorylate tyrosine phosphorylated signalling molecules.SHP-2 plays both positive as well as negative role. It inhibits the activation of MAP kinase in response to insulin and EGF (Epidermal Growth Factor) stimulation. Thus, it shows positive regulation. However, in some cases, it shows negartive regulation of some cellular processes. For example, SHP-2 negatively regulates the Jak-Stat signaling pathway initiated by interferon alpha and gamma. But, the precise biochemical basis for such positive as well as negative regulation for this phosphatase still remains unclear.
Work Step by Step
SHP-2 is a Src homology domain containing protein tyrosine phosphatase (PTP) takes part in regulation of many cellular biological processes. Phosphatases dephosphorylate tyrosine phosphorylated signalling molecules.SHP-2 plays both positive as well as negative role. It inhibits the activation of MAP kinase in response to insulin and EGF (Epidermal Growth Factor) stimulation. Thus, it shows positive regulation. However, in some cases, it shows negartive regulation of some cellular processes. For example, SHP-2 negatively regulates the Jak-Stat signaling pathway initiated by interferon alpha and gamma. But, the precise biochemical basis for such positive as well as negative regulation for this phosphatase still remains unclear.
