Answer
The insulin bind to alpha chain of IRS and due to which reposition of ligand binding domains on the outside of cells. It causes the tyrosine kinase domains to come into close physical proximity and leads to trans autophosporylation and receptor activation.
Work Step by Step
The insulin bind to alpha chain of IRS and due to which reposition of ligand binding domains on the outside of cells. It causes the tyrosine kinase domains to come into close physical proximity and leads to trans autophosporylation and receptor activation.
