Answer
Cholera toxin produced by Vibrio Cholera is a traditional biotoxin and causes the accumulation of cellular cAMP and this will result in the induced differentiation of malignant cells. Hydrolysis of GTP by a variety of guanine nucleotide binding protein is one of the important steps in the regulation of biological switches. So mutations which can modify or impair the activity of GTPase will result in tumor developments in humans. The ADP-ribosylation of an arginine residue in Gsa by cholera toxin inhibits the GTPase activity. Because of this modification there will be an irreversible activation of the G-protein a subunit with corresponding stimulation of its effector, adenylyl cyclase. The inhibition of GTPase activity will result in human malignancies. Cholera toxin won't cause cancer, but the action of cholera toxin on regulating molecules will finally results development of tumors or cancer.
Work Step by Step
Cholera toxin produced by Vibrio Cholera is a traditional biotoxin and causes the accumulation of cellular cAMP and this will result in the induced differentiation of malignant cells. Hydrolysis of GTP by a variety of guanine nucleotide binding protein is one of the important steps in the regulation of biological switches. So mutations which can modify or impair the activity of GTPase will result in tumor developments in humans. The ADP-ribosylation of an arginine residue in Gsa by cholera toxin inhibits the GTPase activity. Because of this modification there will be an irreversible activation of the G-protein a subunit with corresponding stimulation of its effector, adenylyl cyclase. The inhibition of GTPase activity will result in human malignancies. Cholera toxin won't cause cancer, but the action of cholera toxin on regulating molecules will finally results development of tumors or cancer.
