Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 17 - Citric Acid Cycle - Exercises - Page 586: 24

Answer

Beri beri is caused by deficiency of Vitamine B1 (thiamine). Co enzyme of Vitamine B1 is TPP (thiamine pyrophosphate), this catalyze the oxidative decarboxylation reaction catalyzed by PDH, alpha keto gluterate dehydrogenase, brach chain keto acid dehydrogenase. In deficiency of Vitamine B1 pyruvate, alpha keto gluterate (intermediate of TCA cycle), brach chain acids will accumulate. As their catabolism is based on utilization of Vitamine B1.

Work Step by Step

Beri beri is caused by deficiency of Vitamine B1 (thiamine). Co enzyme of Vitamine B1 is TPP (thiamine pyrophosphate), this catalyze the oxidative decarboxylation reaction catalyzed by PDH, alpha keto gluterate dehydrogenase, brach chain keto acid dehydrogenase. In deficiency of Vitamine B1 pyruvate, alpha keto gluterate (intermediate of TCA cycle), brach chain acids will accumulate. As their catabolism is based on utilization of Vitamine B1.
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