Answer
$ -8m^{5/4}-\frac{4}{m^{3/4}}$
Work Step by Step
$-m^{3/4}(8m^{1/2}+4m^{-3/2})=-8m^{(3/4+1/2)}-4m^{(3/4-3/2)}=-8m^{5/4}-4m^{-3/4}=-8m^{5/4}-\frac{4}{m^{3/4}}$
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