Answer
NAD+/NADH are the reduced form of NAD whereas the NADP+/NADPH are the reduced equivalents of NADP. The net charge of both these cofactors is different. NAD+ can accept two electrons and one proton to become reduced to NADH. This reduced form can be further used to donate electrons. Thus, the net charge of NAD+/NADH is -1/-2 whereas that of the other cofactor NADP+/NADPH is -3/-4.
Work Step by Step
NAD+/NADH are the reduced form of NAD whereas the NADP+/NADPH are the reduced equivalents of NADP. The net charge of both these cofactors is different. NAD+ can accept two electrons and one proton to become reduced to NADH. This reduced form can be further used to donate electrons. Thus, the net charge of NAD+/NADH is -1/-2 whereas that of the other cofactor NADP+/NADPH is -3/-4.