Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 14 - Introduction to Metabolism - Exercises - Page 476: 26

Answer

ATP is unstable (i.e high in energy) due to multiple negative charges of 3 phosphate groups. Thus removal of Phosphate group is very spontaneous. AMP is stable compared to ATP as AMP has only 1 negative charge due to 1 phosphate group. AMP is more resonance stabilized than ATP. Hence removal of phosphate group is not spontaneous as that compared to ATP. Sponatenous character is indicated by delta G. Thus ATP hydrolysis being more spontaneous has higher delta Go (twice as large) compared to relatively non spontaneous AMP hydrolysis.

Work Step by Step

ATP is unstable (i.e high in energy) due to multiple negative charges of 3 phosphate groups. Thus removal of Phosphate group is very spontaneous. AMP is stable compared to ATP as AMP has only 1 negative charge due to 1 phosphate group. AMP is more resonance stabilized than ATP. Hence removal of phosphate group is not spontaneous as that compared to ATP. Sponatenous character is indicated by delta G. Thus ATP hydrolysis being more spontaneous has higher delta Go (twice as large) compared to relatively non spontaneous AMP hydrolysis.
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