Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 14 - Introduction to Metabolism - Exercises - Page 476: 35

Answer

a. Compound Q, a metabolic inhibitor of enzyme B, causes Z to build up. Z must be the substrate for B b. A mutant in enzyme C requires Y for growth. The mutant cannot make Y therefore Y must be the product of C. c. An inhibitor of enzyme A causes W, Y and Z to accumulate. The enzyme A inhibitor causes intermediates before it in the pathway to build up. d. Compound P, a metabolic inhibitor of enzyme C, causes W and Z to build up. As above, W and Z come before enzyme C.

Work Step by Step

a. Compound Q, a metabolic inhibitor of enzyme B, causes Z to build up. Z must be the substrate for B b. A mutant in enzyme C requires Y for growth. The mutant cannot make Y therefore Y must be the product of C. c. An inhibitor of enzyme A causes W, Y and Z to accumulate. The enzyme A inhibitor causes intermediates before it in the pathway to build up. d. Compound P, a metabolic inhibitor of enzyme C, causes W and Z to build up. As above, W and Z come before enzyme C.
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