Answer
Why does it make metabolic sense for the same hormone signal to stimulate glycogenolysis and inhibit glycolysis in the liver while stimulating both glycogenolysis and glycolysis in muscles? Answer: above scenario is a classical metabolic response in fight or flight situation controlled by hormone epinephrine (adrenalin). In fight or flight response that controlled by epinephrine stimulate the breakdown of glycogen into glucose (glycogenolysis) to increase the peripheral blood glucose and the same time, it inhibits the glycolysis pathway in the liver so that more glucose can be channelised into the peripheral region that will be available for the muscle to contract. Similarly, epinephrine stimulates glycogenolysis and glycolysis in the muscle to support muscle contraction.
Work Step by Step
Why does it make metabolic sense for the same hormone signal to stimulate glycogenolysis and inhibit glycolysis in the liver while stimulating both glycogenolysis and glycolysis in muscles? Answer: above scenario is a classical metabolic response in fight or flight situation controlled by hormone epinephrine (adrenalin). In fight or flight response that controlled by epinephrine stimulate the breakdown of glycogen into glucose (glycogenolysis) to increase the peripheral blood glucose and the same time, it inhibits the glycolysis pathway in the liver so that more glucose can be channelised into the peripheral region that will be available for the muscle to contract. Similarly, epinephrine stimulates glycogenolysis and glycolysis in the muscle to support muscle contraction.
