Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 16 - Glycogen Metabolism and Gluconeogenesis - Exercises - Page 556: 15

Answer

A) Glycogen----3 G1P (by glycogen phosphorylase) 3 G1P -3 G6P (by phosphoglucomutase) From G6P to 2 pyruvate, input 1 ATP (by phosphofuctoase kinase) output 4 ATP Net yield 3 ATP Thus, from 3 residue of glycogen to 6 pyruvate: 3 x 3 = 9 ATP. (+9). (B)Stage I, input2 ATP per glucose Stage II: output 4 ATP per glucose Net yield is 2 ATP per glucose. Thus, 3 glucose to 6 pyruvate will be 6 ATP.(+6). (C) 2 pyruvate to 1 glucose costs 6 ATP: 2 each at the steps catalyzed by pyruvate carboxylase;PEPCK and phosphoglycerate kinaseThus, 6 pyruvate to 3 glucose needs 18 ATP input(-18).

Work Step by Step

A) Glycogen----3 G1P (by glycogen phosphorylase) 3 G1P -3 G6P (by phosphoglucomutase) From G6P to 2 pyruvate, input 1 ATP (by phosphofuctoase kinase) output 4 ATP Net yield 3 ATP Thus, from 3 residue of glycogen to 6 pyruvate: 3 x 3 = 9 ATP. (+9). (B)Stage I, input2 ATP per glucose Stage II: output 4 ATP per glucose Net yield is 2 ATP per glucose. Thus, 3 glucose to 6 pyruvate will be 6 ATP.(+6). (C) 2 pyruvate to 1 glucose costs 6 ATP: 2 each at the steps catalyzed by pyruvate carboxylase;PEPCK and phosphoglycerate kinaseThus, 6 pyruvate to 3 glucose needs 18 ATP input(-18).
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