Fundamentals of Biochemistry: Life at the Molecular Level 5th Edition

Published by Wiley
ISBN 10: 1118918401
ISBN 13: 978-1-11891-840-1

Chapter 16 - Glycogen Metabolism and Gluconeogenesis - Exercises - Page 556: 23

Answer

Really depends on where the glycogen is made. Formation of glycogen uses one ATP to phosphorylate glucose, and one UTP to activate it. In muscle, when glycogen is broken back down to glucose-1-phosphate, it simply changes to glucose-6-phosphate by phosphoglucomutase, thus there is no loss of extra ATP (since you would need ATP for first step in glycolysis anyways) However, if made in the liver, it must be returned to glucose to transport out to the bloodstream. This means that ATP used during storage is lost, and wasted (in sense) UTP is also a possible ambiguity. UTP is not ATP, but also is an energy source needed to activate glucose for glycogen synthesis. So there are four possibilities in total. -In muscle, not counting UTP: 0/32 = 0 -In muscle, counting UTP: 1/32 = 3.125% -In liver, not counting UTP: 1/32 = 3.125% -In liver, counting UTP: 2/32 = 6.25%

Work Step by Step

Really depends on where the glycogen is made. Formation of glycogen uses one ATP to phosphorylate glucose, and one UTP to activate it. In muscle, when glycogen is broken back down to glucose-1-phosphate, it simply changes to glucose-6-phosphate by phosphoglucomutase, thus there is no loss of extra ATP (since you would need ATP for first step in glycolysis anyways) However, if made in the liver, it must be returned to glucose to transport out to the bloodstream. This means that ATP used during storage is lost, and wasted (in sense) UTP is also a possible ambiguity. UTP is not ATP, but also is an energy source needed to activate glucose for glycogen synthesis. So there are four possibilities in total. -In muscle, not counting UTP: 0/32 = 0 -In muscle, counting UTP: 1/32 = 3.125% -In liver, not counting UTP: 1/32 = 3.125% -In liver, counting UTP: 2/32 = 6.25%
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