Answer
$-\dfrac{1}{16}$
Work Step by Step
The given expression is equivalent to
$-(4^{-2})$
RECALL:
$a^{-m} = \dfrac{1}{a^m}, a \ne 0$
Use the rule above to obtain:
$-(4^{-2}) = -(\dfrac{1}{4^2})=-(\dfrac{1}{16})=-\dfrac{1}{16}$