Answer
The active form of enzyme contains thiolate ion. The increased pK value will increase the nuclophilicity of the thiolate and there by increase the rate of reaction catalysed active form of enzyme. At physiological pH, there would be less of the active form of enzyme and therefore the overall rate would be decreased.
Work Step by Step
The active form of enzyme contains thiolate ion. The increased pK value will increase the nuclophilicity of the thiolate and there by increase the rate of reaction catalysed active form of enzyme. At physiological pH, there would be less of the active form of enzyme and therefore the overall rate would be decreased.
