Answer
Deficiency of factor IX leads to hemophilia B. Factor IX plays an important role in the blood coagulation cascade and activate factor X in combination with membrane phospholipids, factor VIII, and calcium ions activate factor X to its active form Xa. The activated form of factor VII, factor Vlla can also activate factor X when combined with the protein tissue factor (TF), which is released by activated platelets. Since both factor VII and factor IX both function in the initiation phase of blood clotting to activate factor X, a deficiency of factor IX can also be compensated by providing an excess of factor VII. This is assuming that an infusion of factor IX is unavailable.
Work Step by Step
Deficiency of factor IX leads to hemophilia B. Factor IX plays an important role in the blood coagulation cascade and activate factor X in combination with membrane phospholipids, factor VIII, and calcium ions activate factor X to its active form Xa. The activated form of factor VII, factor Vlla can also activate factor X when combined with the protein tissue factor (TF), which is released by activated platelets. Since both factor VII and factor IX both function in the initiation phase of blood clotting to activate factor X, a deficiency of factor IX can also be compensated by providing an excess of factor VII. This is assuming that an infusion of factor IX is unavailable.
